xian.chem.wsu.eduMing Xian Research Group | Washington State University

Skip to main content Skip to navigation Department of Chemistry Ming Xian Research Group Welcome to the Xian Group Attention Perspective Students: If you are interested in joining the Xian laboratory for your PhD training, please contact Dr. Xian directly and email him your CV, transcripts (unofficial), personal statement. Dr. Xian will evaluate your profile, facilitate your application, and even reimburse your application fee! Our group is working on the interface between chemistry and biology. We are especially interested in the research related to signaling molecules. Redox signaling molecules such as nitric oxide (NO) and hydrogen sulfide (H 2 S) play important roles in a number of physiological and pathophysiological processes. The detailed understanding of their biological functions is challenging because these molecules are very reactive and can undergo many possible biochemical reactions to form complicated products. Our long-term goal is to understand the fundamental mechanisms of NO and H 2 S related to their functions. In this field researchers have limited access of tools to mimic biological generation of these signaling molecules and monitor their fates in biological systems. Our lab has been actively exploring such chemical tools and has identified some promising candidates. We hope our efforts will ultimately lead to a better understanding of the significance of NO and H 2 S and initiate new strategies of related therapy. Our lab is located in Troy Hall (rooms 201, 203, and 205). We enjoy our research and life in the beautiful Pullman campus. You are welcome to visit our group! Thank you for visiting the website of Dr. Ming Xian’s group! H2S fluorescent sensor database: http://sensor.eecs.wsu.edu/index/ News and Events June 2019 – Our selenylsulfide work was accepted by Organic Letters. Congrats to Akil and co-authors. June 2019 – Our H2S scavenger work has been highlighted by C&EN, check this link https://cen.acs.org/synthesis/medicinal-chemistry/Datamining-hydrogen-sulfide-antidote/97/i26?utm_source=Newsletter&utm_medium=Newsletter&utm_campaign=CEN June 2019 – Our H2S scavenger work has been published in Angew Chem Int Ed. May 2019 – Mr. Jacob Day has completed his PhD at WSU and is going to Northwestern University for his postdoc training with Prof. Richard Silverman. Ms. Deshka Neill has completed her undergraduate training and is going to UC Berkeley for her PhD degree. Thank you for your hard work in our lab. You will be missed. Wish you all the best! June 2018 – H2S fluorescent sensor database is on-line. Thanks NSF for funding this project! You can find info about all reported sensors: http://sensor.eecs.wsu.edu/index/ May 2018 – Jianming successfully defended his Ph.D. Congratulations Dr. Kang! April 2018 – Our work on O to S relay deprotection for the design of donors for reactive sulfur species has been published in Angew Chem Int Ed. April 2018 – Deshka Neill won the top award-Crimson Award (1st place) in WSU Showcase for Undergraduate Research and Creative Activities (SURCA). Good job Deshka! March 2018 – Jake Day is awarded the Anne and Russ Fuller Fellowship. Our review article about hydrogen polysulfides have been accepted by Br. J. Pharmacol. Congratulations! January 2018 – Our work on cyclic acyl disulfides/selenylsulfides has been published in Org. Lett. Congratulations to Jianming, Aaron, Wei. January 2018 – Jianming just got married! Congratulations!! January 2018 – Our work on trisulfide synthesis has been accepted by Organic Letters. Congratulations to Steve, Yingying, Miles, and Aaron! December 2017 – Congratulations to Wei Chen for his Angew paper on the new fluorescent dyes, the Washington Red series. See the news: https://news.wsu.edu/2017/12/11/bioimaging-dye-breakthrough/ December 2017 – Welcome the new visiting professor-Dr. Heng Liu from Hubei University, China August 2017- We have completed our move to a completely remodeled Troy Hall!! June 2017 – Congratulations to Armando and Tyler for completing their PhD!!!! May 2017 – Congratulations to Jacob Day for receiving the Ruth L. Kirschstein National Research Service Award, aka NIH F31predoctoral fellowship. See the news: https://news.wsu.edu/2017/05/09/chemistry-student-mistake-becomes-fellowship/ July 2015 – Congratulations to Steve on his marriage to Yingying Wang! Congratulations to Armando and Jianming on their publication in the Journal of Medicinal Chemistry on the cardioprotective effects of N -mercapto based hydrogen sulfide donors! June 2015 – Congratulations to Tyler, on his engagement to Karin! May 2015 – Congratulations to Bo, for being awarded the RA of the Year in the Chemistry Department. May 2015 – Congratulations to Wei, Ethan, and Di for publishing their work on a new hydrogen polysulfide probe in Org. Lett. Congratulations to Chung-Min, Laksiri, and Jake for publishing a review on persulfides in Mol. BioSyst. April 2015 – Our work on Phosphine Mediated Conjugation of S-Nitrosothiols and Aldehydes has been published in Tet. Lett. Congratulations to Tyler, Laksiri and Chung-Min! Feb 2015 – Our work on diselenide based H 2 S fluorescent probes was published in Org. Lett. Congratulations to Bo, Armando, and Wei! November 2014 – Our three protocol papers on H 2 S donors and sensors have been published in Methods in Enzymology, congratulations to Bo and Chung-Min! September 2014 – We welcome two new graduate students to join our lab: Jake Day and Steve Xu. August 2014 – We welcome a new postdoctoral researcher-Dr. Laksiri Weerasinghe. August 2014 – Our work on thio-activated gem-dithiol based H 2 S donors has been published in Org. Lett, congratulations to Yu, Jianming, Chung-Min, and Powell! In addition, another work on isotope dilution mass method for sulfane sulfur detection has been published in Free Radical Biol. Med. Congratulations to Chunrong! July 2014 – Congratulations to Yu on the completion of his doctorate! May 2014 – Our paper entitled “Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides” has been published in the Journal of the American Chemical Society. Congratulations to Chungrong , Wei , Bo and Yu ! May 2014 – Congratulations to our undergraduate, Brett Johnson , for being awarded a summer mini-grant! April 2014 – Three group members received awards in 2014 Chemistry Department Awards and Recognition Banquet. Armando Pacheco is the 2014 TA of the Year; Bo Peng received the Donald S. Matteson Graduate Fellowship; Yu Zhao received the Gardner Stacy Research Scholarship. Congratulations! March 2014 – Our work on hydrogen sulfide has been made the news! Original Article March 2014 – Our group welcomes a new visiting scholar, Dr. Caihong Zhang , from Shanxi University, China. March 2014 – Our collaborative work (with Prof. Akaike and Prof. Fukuto), entitled “Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling” has been accepted for publication in Proc. Natl. Acad. Sci. USA. Congratulations! March 2014 – Our paper entitled “A reductive ligation based fluorescent probe for S-nitrosothiols” has been accepted for publication in Chemical Communications. Congratulations Di and Wei ! February 2014 – Congratulations to Ethan for receiving NASA Space Grant Undergraduate Scholarship. Also, Ethan has been awarded the Undergraduate Award in Organic Chemistry by American Chemical Society’s Division of Organic Chemistry. Excellent work! February 2014 – Our paper entitled “Detection of Protein S-Sulfhydration by a Tag-Switch Technique.” has been selected as a hot paper for the months January/February of European Network on Gasotransmitters. Good job! November 2013 – Our work entitled “Detection of Protein S-Sulfhydration by a Tag-Switch Technique.” has been accepted for publication in Angewandte Chemie International Edition. Congrats! Dehui , Nelmi , Chung-Min , and Jia . October 2013 – Congrats! to Ethan for receiving Sciences U...